Holland E J, Chan C C, Kuwabara T, Palestine A G, Rowsey J J, Nussenblatt R B
Department of Ophthalmology, University of Minnesota, Minneapolis 55455.
Am J Ophthalmol. 1989 Feb 15;107(2):160-6. doi: 10.1016/0002-9394(89)90216-x.
Using immunohistochemical techniques, we studied ligneous conjunctival lesions from two patients. A significant immune reaction was detected that was characterized by activated T lymphocytes and focal accumulation of plasma cells and B lymphocytes. Immunofluorescent studies demonstrated that IgG was a prominent component of the amorphous hyaline material seen in these lesions. After previous treatment methods had failed, both patients were treated with excisional biopsy and topical cyclosporine. Patient 1 had a dramatic response, with complete resolution of the lesions. Patient 2 had a significant improvement resulting in small, slow-growing recurrences instead of the rapid and extensive recurrences that occurred before treatment with cyclosporine.
我们运用免疫组化技术研究了两名患者的木样结膜病变。检测到显著的免疫反应，其特征为活化的T淋巴细胞以及浆细胞和B淋巴细胞的局灶性聚集。免疫荧光研究表明，IgG是这些病变中所见无定形透明质材料的主要成分。在先前的治疗方法均告失败后，两名患者均接受了切除活检和局部使用环孢素治疗。患者1有显著反应，病变完全消退。患者2有明显改善，复发较小且生长缓慢，而非环孢素治疗前出现的迅速广泛复发。
