IJsselstijn Hanneke, Gischler Saskia J, Toussaint Leontien, Spoel Marjolein, Zijp Monique H M van der Cammen-van, Tibboel Dick
Department of Intensive Care and Paediatric Surgery, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.
Department of Intensive Care and Paediatric Surgery, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.
Paediatr Respir Rev. 2016 Jun;19:34-8. doi: 10.1016/j.prrv.2015.07.003. Epub 2015 Jul 23.
Survival rates in oesophageal atresia patients have reached over 90%. In long-term follow-up studies the focus has shifted from purely surgical or gastrointestinal evaluation to a multidisciplinary approach. We reviewed the literature on the long-term morbidity of these patients and discuss mainly issues of physical growth and neurodevelopment. We conclude that growth problems - both stunting and wasting - are frequently seen, but that sufficient longitudinal data are lacking. Therefore, it is unclear whether catch-up growth into adolescence and adulthood occurs. Data on determinants of growth retardation are also lacking in current literature. Studies on neurodevelopment beyond preschool age are scarce but oesophageal atresia patients seem at risk for academic problems and motor function delay. Many factors contribute to the susceptibility to growth and development problems and we propose a multidisciplinary follow-up schedule into adulthood future care which may help improve quality of life.
食管闭锁患者的存活率已超过90%。在长期随访研究中，重点已从单纯的手术或胃肠道评估转向多学科方法。我们回顾了有关这些患者长期发病率的文献，并主要讨论身体生长和神经发育问题。我们得出结论，生长问题——发育迟缓与消瘦——都很常见，但缺乏足够的纵向数据。因此，尚不清楚是否会在青春期和成年期出现追赶性生长。目前的文献中也缺乏关于生长发育迟缓决定因素的数据。学龄前儿童之后的神经发育研究很少，但食管闭锁患者似乎有学业问题和运动功能延迟的风险。许多因素导致了生长发育问题的易感性，我们建议制定一个到成年期的多学科随访计划，这可能有助于提高生活质量。
