Filipek P A, Kennedy D N, Caviness V S, Rossnick S L, Spraggins T A, Starewicz P M
Pediatric Neurology Service, Massachusetts General Hospital, Harvard Medical School, Boston 02114.
Ann Neurol. 1989 Jan;25(1):61-7. doi: 10.1002/ana.410250110.
A semiautomated computerized method of in vivo morphometric analysis that is based upon high-resolution three-dimensional magnetic resonance imaging has been developed. This morphometric method is efficient and is of greater analytical precision than any other morphometric method currently applied to living human tissue. Including error inherent in image data acquisition, the aggregate error of the methodology, as estimated by the phantom studies, ranges from 4.5 to 9.6%, with incremental error above 4.5% a function of magnetic resonance slice thickness. This method was applied to magnetic resonance scans of 7 normal volunteers. The derived volumes of whole brain and of individual substructures were closely concordant with previously published volumes of normal fresh (unfixed) brains obtained post mortem. This morphometric methodology is potentially applicable to any structure or lesion that can be visualized by magnetic resonance imaging.
一种基于高分辨率三维磁共振成像的半自动计算机化体内形态计量分析方法已经开发出来。这种形态计量方法效率高，并且比目前应用于活体人体组织的任何其他形态计量方法具有更高的分析精度。包括图像数据采集固有的误差，通过体模研究估计，该方法的总误差范围为4.5%至9.6%，超过4.5%的增量误差是磁共振切片厚度的函数。该方法应用于7名正常志愿者的磁共振扫描。得出的全脑和各个子结构的体积与先前发表的死后获得的正常新鲜（未固定）大脑的体积密切一致。这种形态计量方法有可能应用于任何可通过磁共振成像可视化的结构或病变。
