生物钟：意想不到的生化齿轮。
Circadian Clocks: Unexpected Biochemical Cogs.
作者信息
Mori Tetsuya, Mchaourab Hassane, Johnson Carl Hirschie
机构信息
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.
Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37235, USA.
出版信息
Curr Biol. 2015 Oct 5;25(19):R842-4. doi: 10.1016/j.cub.2015.08.026.
Abstract
A circadian oscillation can be reconstituted in vitro from three proteins that cycles with a period of ∼ 24 h. Two recent studies provide surprising biochemical answers to why this remarkable oscillator has such a long time constant and how it can switch effortlessly between alternating enzymatic modes.
摘要
一种昼夜节律振荡可以在体外由三种蛋白质重建，其周期约为24小时。最近的两项研究为这个非凡的振荡器为何具有如此长的时间常数以及它如何能在交替的酶促模式之间轻松切换提供了惊人的生化答案。
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