Cheng Chen, Zhang Haolin, Zhao Yue, Li Rong, Qiao Jie
Reproductive Medical Centre, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, People's Republic of China.
Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, People's Republic of China.
J Assist Reprod Genet. 2015 Dec;32(12):1731-9. doi: 10.1007/s10815-015-0587-y. Epub 2015 Oct 6.
The purpose of the present study is to determine if paternal or maternal history of diabetes mellitus (DM) and hypertension (HT) contributes to the prevalence and phenotype of polycystic ovary syndrome (PCOS).
We performed an epidemiologic study about PCOS from four districts in Beijing, China, between 2008 and 2009. Parental histories of DM and HT were collected, and the basic characteristics and serum indices of 123 PCOS patients and 718 non-PCOS controls were tested.
The prevalence of a parental history of DM and HT was significantly higher in PCOS patients than non-PCOS women (17.1 % vs. 9.2 % and 42.3 % vs. 26.0 %, P < 0.05, respectively). When paternal history was separated from maternal history, only a paternal history of DM and HT reached statistical significance between PCOS and non-PCOS patients (odds ratio (OR) = 3.42, 95 % confidence interval (CI) = 1.69-6.91; OR = 2.50, 95 % CI = 1.58-3.93, respectively). A paternal history of both DM and HT was significantly associated with sex hormone-binding globulin, fasting plasma glucose, and fasting insulin levels, the free androgen index, and the homeostatic model assessment-insulin resistance in PCOS patients (P < 0.05 for all). There was no independent association between maternal history and the clinical or biochemical phenotype of PCOS.
PCOS patients with a positive paternal history of both DM and HT have an adverse endocrine and metabolic profile. A paternal history of DM and HT poses a risk to PCOS.
本研究旨在确定糖尿病（DM）和高血压（HT）的父系或母系家族史是否会影响多囊卵巢综合征（PCOS）的患病率及表型。
2008年至2009年间，我们在中国北京四个区开展了一项关于PCOS的流行病学研究。收集了父母的DM和HT家族史，并检测了123例PCOS患者和718例非PCOS对照者的基本特征及血清指标。
PCOS患者的父母有DM和HT家族史的患病率显著高于非PCOS女性（分别为17.1%对9.2%和42.3%对26.0%，P<0.05）。当将父系家族史与母系家族史分开分析时，只有父系的DM和HT家族史在PCOS患者与非PCOS患者之间具有统计学意义（优势比（OR）分别为3.42，95%置信区间（CI）=1.69 - 6.91；OR = 2.50，95%CI = 1.58 - 3.93）。父系的DM和HT家族史均与PCOS患者的性激素结合球蛋白、空腹血糖、空腹胰岛素水平、游离雄激素指数及稳态模型评估胰岛素抵抗显著相关（均P<0.05）。母系家族史与PCOS的临床或生化表型之间无独立关联。
父母有DM和HT家族史阳性的PCOS患者具有不良的内分泌和代谢特征。父系的DM和HT家族史会增加患PCOS的风险。
