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骨骼肌线粒体对运动训练的适应性

Adaptations of skeletal muscle mitochondria to exercise training.

作者信息

Lundby Carsten, Jacobs Robert A

机构信息

Zürich Center for Integrative Human Physiology, Institute of Physiology, University of Zürich, Zürich, Switzerland.

Health and Physical Education, School of Teaching and Learning, Western Carolina University, Cullowhee, NC, USA.

出版信息

Exp Physiol. 2016 Jan;101(1):17-22. doi: 10.1113/EP085319. Epub 2015 Nov 17.

DOI:10.1113/EP085319
PMID:26440213
Abstract

Mitochondrial volume density (Mito(VD)) is composed of two distinct mitochondrial subpopulations--intermyofibrillar mitochondria (Mito(IMF)) and subsarcolemmal mitochondria (Mito(SS)). With exercise training, Mito(VD) may increase by up to 40% and is, for the most part, related to an increase in Mito(IMF). Exercise-induced adaptations in mitochondrial function depend on the intensity of training and appear to be explained predominately by an increased expression of mitochondrial enzymes that facilitate aerobic metabolism. Although mitochondrial content often increases with training, it seems that mitochondrial adaptations are not needed to facilitate maximal oxygen uptake, whereas such adaptations are of greater importance for endurance capacity.

摘要

线粒体体积密度(Mito(VD))由两个不同的线粒体亚群组成——肌原纤维间线粒体(Mito(IMF))和肌膜下线粒体(Mito(SS))。通过运动训练,Mito(VD)可能会增加高达40%,并且在很大程度上与Mito(IMF)的增加有关。运动诱导的线粒体功能适应性变化取决于训练强度,并且似乎主要由促进有氧代谢的线粒体酶表达增加来解释。尽管线粒体含量通常会随着训练而增加,但似乎线粒体适应性变化并非促进最大摄氧量所必需,而这种适应性变化对耐力能力更为重要。

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