Yan X X, Yu C P, Fu X A, Bao F F, Du D H, Wang C, Wang N, Wang S F, Shi Z X, Zhou G Z, Tian H Q, Liu H, Zhang F R
Shandong Clinical College of Skin Diseases, Anhui Medical University, Jinan, Shandong, China.
Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, Shandong, China.
Br J Dermatol. 2016 Jan;174(1):176-9. doi: 10.1111/bjd.14082. Epub 2015 Nov 17.
Corynespora cassiicola is a plant pathogen associated with leaf-spotting disease. The fungus has been found on diverse substrates: leaves, stems and roots of plants; nematode cysts and human skin. It rarely causes human infections. Here we report one case of subcutaneous phaeohyphomycosis caused by C. cassiicola with prominent tissue necrosis in a woman. All of her clinical features pointed towards a genetic linkage. Hence, whole-exome sequencing and Sanger sequencing were performed on this patient. One mutation of CARD9 was detected.
胶孢炭疽菌是一种与叶斑病相关的植物病原体。这种真菌已在多种基质上被发现：植物的叶子、茎和根；线虫囊肿和人类皮肤。它很少引起人类感染。在此，我们报告一例由胶孢炭疽菌引起的皮下暗色丝孢霉病病例，该病例发生在一名女性身上，伴有明显的组织坏死。她所有的临床特征都指向一种基因关联。因此，对该患者进行了全外显子组测序和桑格测序。检测到CARD9基因的一个突变。
