Yamada Masami, Mochizuki Kazuki, Honma Kazue, Miyauchi Rie, Kasezawa Nobuhiko, Tohyama Kazushige, Goda Toshinao
Laboratory of Nutritional Physiology, University of Shizuoka, Graduate School of Nutritional and Environmental Sciences.
J Nutr Sci Vitaminol (Tokyo). 2015;61(4):291-8. doi: 10.3177/jnsv.61.291.
We wished to examine potential associations among blood concentrations of fatty acid-binding protein (FABP) 4 and parameters in health check-ups such as abdominal fat area (AFA) and blood pressure (BP) in middle-aged Japanese males. We conducted a cross-sectional study of males who participated in health check-ups in Japan. We excluded participants diagnosed with metabolic diseases by the time of their check-up. A total of 305 subjects (30-64 [mean±standard deviation, 47.3±8.5] y) were recruited. Areas of total-abdominal, visceral and subcutaneous fat were measured using computed tomography. We compared the association of serum concentrations of FABP4 with various clinical parameters by Pearson product-moment correlation coefficient (PPMCC) analyses, and by step-wise multivariate linear regression analyses (MLRA). PPMCC analyses showed that blood concentrations of FABP4 were positively associated with: body mass index; areas of fat (total abdominal, visceral, subcutaneous); systolic BP; diastolic BP; total cholesterol; low-density lipoprotein-cholesterol; triacylglycerol; activities of γ-glutamyl transpeptidase, aspartate aminotransferase and alanine aminotransferase; white blood cell count; and levels of creatinine. Step-wise MLRA showed that AFAs (visceral and subcutaneous) and diastolic BP were positively and independently associated with serum concentrations of FABP4 among the parameters tested. These data suggest that serum concentrations of FABP4 are independently and positively associated with BP and AFA among parameters measured in health check-ups in middle-aged Japanese males.
我们希望研究日本中年男性脂肪酸结合蛋白（FABP）4的血液浓度与健康检查中的参数（如腹部脂肪面积（AFA）和血压（BP））之间的潜在关联。我们对参与日本健康检查的男性进行了一项横断面研究。我们排除了在检查时被诊断患有代谢疾病的参与者。共招募了305名受试者（30 - 64岁[均值±标准差，47.3±8.5]）。使用计算机断层扫描测量腹部总脂肪、内脏脂肪和皮下脂肪的面积。我们通过Pearson积矩相关系数（PPMCC）分析以及逐步多元线性回归分析（MLRA）比较了FABP4血清浓度与各种临床参数之间的关联。PPMCC分析表明，FABP4的血液浓度与以下指标呈正相关：体重指数；脂肪面积（腹部总脂肪、内脏脂肪、皮下脂肪）；收缩压；舒张压；总胆固醇；低密度脂蛋白胆固醇；三酰甘油；γ-谷氨酰转肽酶、天冬氨酸转氨酶和丙氨酸转氨酶的活性；白细胞计数；以及肌酐水平。逐步MLRA表明，在测试的参数中，AFA（内脏和皮下）和舒张压与FABP4的血清浓度呈正相关且独立相关。这些数据表明，在日本中年男性的健康检查中，FABP4的血清浓度与血压和AFA在测量参数中呈独立正相关。
