Division of Sociological Approach in Dentistry, Department of Dental Sociology, Kanagawa Dental College, Yokosuka, Japan.
J Periodontol. 2011 Jan;82(1):106-13. doi: 10.1902/jop.2010.100211. Epub 2010 Aug 3.
Limited research has been reported on the relationship between periodontal status and erythrocyte parameters. In the present study, longitudinal data from health checkups are used to clarify the relationship between periodontal disease progression and changes in parameters of erythrocytes.
In this prospective study, a total of 120 subjects (35 men and 85 women; age range: 30 to 63 years) participated in a comprehensive health screening and dental checkup in 2006 and 2007. Medical examinations, including anthropometric and manometric measurements, blood-chemistry tests, and oral examinations, were performed. Subjects with periodontal disease progression (i.e., the progression group) were defined based on the presence of ≥1 tooth demonstrating a longitudinal loss of periodontal attachment ≥3 mm or tooth loss during the study period. The Wilcoxon signed-rank, χ(2), Fisher exact, and Mann-Whitney U tests and stepwise logistic regression analysis were used for statistical analyses.
The progression group comprised 30 subjects. A significant difference between the progression and non-progression groups was observed in changes of erythrocyte counts but not those of the body mass index, systolic and diastolic blood pressure, creatinine, fasting blood glucose, hemoglobin, hematocrit, triglycerides, high- and low-density lipoprotein cholesterol, total cholesterol, aspartate and alanine aminotransferase, and γ-glutamyl transpeptidase. Stepwise logistic regression analysis showed that the progression of periodontal disease was associated with a change (year 2007 minus year 2006) of erythrocyte counts (adjusted odds ratio = 0.970; P = 0.009) after adjusting for age at baseline.
Within the limitations of this study, the progression of periodontal disease is associated with a decrease in erythrocyte counts in a rural Japanese population.
牙周状况与红细胞参数之间的关系的相关研究较少。本研究使用健康检查的纵向数据来阐明牙周病进展与红细胞参数变化之间的关系。
在这项前瞻性研究中，共有 120 名受试者（35 名男性和 85 名女性；年龄范围：30 至 63 岁）参加了 2006 年和 2007 年的全面健康检查和牙科检查。进行了体格检查、血压测量、血液化学检查和口腔检查。根据在研究期间是否存在≥1 颗牙出现牙周附着丧失≥3 毫米或牙齿丧失的情况，将牙周病进展的受试者（即进展组）定义为牙周病进展。使用 Wilcoxon 符号秩和检验、卡方检验、Fisher 确切概率检验、Mann-Whitney U 检验和逐步逻辑回归分析进行统计学分析。
进展组包括 30 名受试者。在红细胞计数的变化方面，进展组与非进展组之间存在显著差异，但在体重指数、收缩压和舒张压、肌酐、空腹血糖、血红蛋白、血细胞比容、甘油三酯、高低密度脂蛋白胆固醇、总胆固醇、天冬氨酸转氨酶和丙氨酸转氨酶以及γ-谷氨酰转肽酶方面没有差异。逐步逻辑回归分析显示，牙周病的进展与红细胞计数的变化（2007 年减去 2006 年）相关（调整后的优势比=0.970；P=0.009），调整了基线时的年龄。
在本研究的限制范围内，牙周病的进展与日本农村人群的红细胞计数减少有关。
