Crespo Inma, Toledo Diana, Soldevila Núria, Jordán Iolanda, Solano Rubén, Castilla Jesús, Caylà Joan A, Godoy Pere, Muñoz-Almagro Carmen, Domínguez Ángela
CIBER Epidemiology and Public Health. Barcelona, Spain; Public Health Department, University of Barcelona, Barcelona, Spain.
Public Health Department, University of Barcelona, Barcelona, Spain; Public Health Agency, Barcelona, Spain.
PLoS One. 2015 Oct 6;10(10):e0139993. doi: 10.1371/journal.pone.0139993. eCollection 2015.
Pertussis causes a large number of cases and hospitalizations in Catalonia and Navarra. We made a study of household cases of pertussis during 2012 and 2013 in order to identify risk factors for hospitalization in pertussis cases. Each primary case reported triggered the study of their contacts. Close contacts at home and people who were in contact for >2 hours during the transmission period of cases were included. The adjusted OR and 95% confidence intervals (CI) was calculated using logistic regression. A total of 1124 pertussis cases were detected, of which 14.9% were hospitalized. Inspiratory whoop (aOR: 1.64; CI: 1.02-2.65), apnoea (aOR: 2.47; CI: 1.51-4.03) and cyanosis (aOR: 15.51; CI: 1.87-128.09) were more common in hospitalized than in outpatient cases. Hospitalization occurred in 8.7% of correctly-vaccinated cases, 41.1% of non-vaccinated cases and 9.4% of partially-vaccinated cases. In conclusion, inspiratory whoop, apnoea and cyanosis were associated factors to hospitalization while vaccination reduced hospitalizations due to pertussis.
百日咳在加泰罗尼亚和纳瓦拉导致了大量病例和住院情况。我们对2012年和2013年的家庭百日咳病例进行了研究，以确定百日咳病例住院的危险因素。每例报告的原发病例都会引发对其接触者的研究。纳入了家中的密切接触者以及在病例传播期接触超过2小时的人员。使用逻辑回归计算调整后的比值比（OR）和95%置信区间（CI）。共检测到1124例百日咳病例，其中14.9%住院治疗。吸气性哮吼（调整后的OR：1.64；CI：1.02 - 2.65）、呼吸暂停（调整后的OR：2.47；CI：1.51 - 4.03）和发绀（调整后的OR：15.51；CI：1.87 - 128.09）在住院病例中比门诊病例中更常见。正确接种疫苗的病例中有8.7%住院，未接种疫苗的病例中有41.1%住院以及部分接种疫苗的病例中有9.4%住院。总之，吸气性哮吼、呼吸暂停和发绀是住院的相关因素，而接种疫苗减少了百日咳导致的住院情况。
