Cook Michael T, Khutoryanskiy Vitaliy V
Department of Pharmacy, University of Hertfordshire, Hatfield AL10 9AB, UK.
School of Pharmacy, University of Reading, Reading RG6 6AD, UK.
Int J Pharm. 2015 Nov 30;495(2):991-8. doi: 10.1016/j.ijpharm.2015.09.064. Epub 2015 Oct 9.
Mucoadhesion describes an attractive interaction between dosage form and mucosal membrane. The evaluation of mucoadhesive excipients often requires the use of ex vivo mucosal tissues taken from laboratory animals. These can be difficult to source, highly heterogeneous, and require the use of animal products. Thus, from both a user-convenience and ethical point-of-view, it is desirable to produce a synthetic alternative to these tissues-a mucosa-mimetic material. In this mini-review, the use of alternative materials to test the performance of mucoadhesives is reviewed and discussed. There is a surprising prevalence of the use of mucosa-mimics in the literature, which hitherto has not been compiled and compared.
黏膜黏附描述了剂型与黏膜之间的一种吸引性相互作用。对黏膜黏附性辅料的评估通常需要使用从实验动物获取的离体黏膜组织。这些组织可能难以获取、高度异质性，并且需要使用动物制品。因此，从用户便利性和伦理角度来看，期望生产出这些组织的合成替代品——一种黏膜模拟材料。在这篇小型综述中，对用于测试黏膜黏附剂性能的替代材料的使用进行了综述和讨论。文献中黏膜模拟物的使用令人惊讶地普遍，迄今为止尚未进行汇编和比较。
