Department of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2C, 15-222 Białystok, Poland.
Institute of Chemistry, University of Białystok, Ciołkowskiego 1K, 15-245 Białystok, Poland.
Int J Mol Sci. 2023 Jun 28;24(13):10793. doi: 10.3390/ijms241310793.
Fungal infections are a group of diseases which are challenging to treat because of drug-resistant fungi species, drug toxicity, and often severe patient conditions. Hence, research into new treatments, including new therapeutic substances and novel drug delivery systems, is being performed. Mucoadhesive dosage forms are beneficial to improving drug bioavailability by prolonging the residence time at the site of application. Sodium alginate is a natural polymer with favorable mucoadhesive and gelling properties, although its precipitation in acidic pH significantly disrupts the process of drug release in gastric conditions. Hypromellose is a hydrophilic, semi-synthetic cellulose derivative with mucoadhesive properties, which is widely used as a control release agent in pharmaceutical technology. The aim of this study was to evaluate the impact of hypromellose on alginate microparticles with posaconazole, designed to modify drug release and to improve their mucoadhesive properties for both oral or vaginal application.
真菌感染是一组疾病，由于耐药真菌物种、药物毒性以及患者病情常常较为严重，这些疾病的治疗极具挑战性。因此，正在进行新治疗方法的研究，包括新的治疗物质和新型药物输送系统。黏膜粘附剂型通过延长在应用部位的停留时间有益于提高药物生物利用度。海藻酸钠是一种具有良好黏膜粘附性和胶凝特性的天然聚合物，尽管其在酸性 pH 值下沉淀会显著破坏胃环境中药物释放的过程。羟丙甲纤维素是一种亲水性、半合成纤维素衍生物，具有黏膜粘附特性，广泛用作药物技术中的控制释放剂。本研究的目的是评估羟丙甲纤维素对含有泊沙康唑的海藻酸钠微球的影响，旨在修饰药物释放并改善其用于口服或阴道应用的黏膜粘附特性。
