Saleem Faryal, Fasih Naima, Zafar Afia
Department of Pathology and Microbiology, Aga Khan University Hospital, Karachi, Pakistan.
J Pak Med Assoc. 2015 Oct;65(10):1122-4.
Meningitis is a serious disease associated with considerable morbidity and mortality. Mixed meningeal infections due to bacteria and fungi are exceptionally rare. Here we report a case of meningeal co-infection with cryptococcus neoformans and streptococcus pneumoniae in a patient with unknown human immunodeficiency virus status. Because of the rarity of such cases, stringent screening of every cerebrospinal fluid specimen to exclude the presence of multiple pathogens is imperative. Assessment of patients for immunodeficiencies in case of isolation of an opportunistic organism like cryptococcus is also needed.
脑膜炎是一种与高发病率和死亡率相关的严重疾病。由细菌和真菌引起的混合性脑膜感染极为罕见。在此，我们报告一例人类免疫缺陷病毒（HIV）感染状况不明的患者发生新型隐球菌和肺炎链球菌脑膜合并感染的病例。由于此类病例罕见，对每份脑脊液标本进行严格筛查以排除多种病原体的存在至关重要。对于分离出如隐球菌等机会性生物体的患者，也需要评估其免疫缺陷情况。
