记忆性T细胞在器官移植中的作用及干预前景
Role of Memory T Cells and Perspectives for Intervention in Organ Transplantation.
作者信息
Lin Kailin, Chen Song, Chen Gang
机构信息
Institute of Organ Transplantation, Tongji Hospital, Huazhong University of Science and Technology , Wuhan , China.
Institute of Organ Transplantation, Tongji Hospital, Huazhong University of Science and Technology , Wuhan , China ; Key Laboratory of Organ Transplantation, Ministry of Education , Wuhan , China ; Key Laboratory of Organ Transplantation, Ministry of Public Health , Wuhan , China.
出版信息
Front Immunol. 2015 Sep 14;6:473. doi: 10.3389/fimmu.2015.00473. eCollection 2015.
Abstract
Memory T cells are necessary for protective immunity against invading pathogens, especially under conditions of immunosuppression. However, their presence also threatens transplant survival, making transplantation a great challenge. Significant progress has been achieved in recent years in advancing our understanding of the role that memory T cells play in transplantation. This review focuses on the latest advances in our understanding of the involvement of memory T cells in graft rejection and transplant tolerance and discusses potential strategies for targeting memory T cells in order to minimize allograft rejection and optimize clinical outcomes.
摘要
记忆性T细胞对于抵御入侵病原体的保护性免疫是必需的，尤其是在免疫抑制条件下。然而，它们的存在也威胁着移植器官的存活，这使得移植成为一项巨大的挑战。近年来，在增进我们对记忆性T细胞在移植中所起作用的理解方面取得了重大进展。本综述重点关注我们对记忆性T细胞参与移植排斥和移植耐受的理解的最新进展，并讨论针对记忆性T细胞的潜在策略，以尽量减少同种异体移植排斥并优化临床结果。
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