Xing Jianhua, Lee Robin E C
Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Sci Signal. 2015 Oct 6;8(397):fs17. doi: 10.1126/scisignal.aad2816.
Gradients of transmembrane potential coordinate cell-fate decisions and patterning during embryogenesis and wound-healing. Bioelectrical signaling may also be more important for adult pathologies than currently recognized. In this issue of Science Signaling, Lobikin et al. describe a role for bioelectric signals during the development of Xenopus leavis embryos to instruct an organism-level response reminiscent of neoplastic progression in melanoma.
跨膜电位梯度在胚胎发育和伤口愈合过程中协调细胞命运决定和模式形成。生物电信号对于成人疾病可能也比目前所认识到的更为重要。在本期《科学信号》中，洛比金等人描述了非洲爪蟾胚胎发育过程中生物电信号的一种作用，即指导一种类似于黑色素瘤肿瘤进展的机体水平反应。
