Lan Yuan-Tzu, Huang Kuo-Hung, Liu Chien-An, Tai Ling-Chen, Chen Ming-Huang, Chao Yee, Li Anna Fen-Yau, Chiou Shih-Hwa, Shyr Yi-Ming, Wu Chew-Wun, Fang Wen-Liang
Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Clinical Medicine, School of Medicine, National Yang-Ming University.
PLoS One. 2015 Oct 7;10(10):e0139748. doi: 10.1371/journal.pone.0139748. eCollection 2015.
Adenosquamous carcinoma (ASC) is a rare disease involving various organs, yet there are no large-scale population-based comparative studies on ASC among different organs.
The incidence and overall survival of ASC among various organs in cases diagnosed in Taiwan from January 1, 2003 to December 31, 2010 were calculated and compared using data from the Taiwan Cancer Registry (TCR). The various organs were classified and divided into three different systems: the female reproductive, respiratory, and alimentary systems. Survival analysis were also compared among 30,850 patients diagnosed as ASC, adenocarcinoma (AC) or squamous cell carcinoma (SCC) in organs with frequent ASC.
During the study period, a total of 576 ASC cases were diagnosed in Taiwan. The most common primary system was respiratory (73.8%), followed by alimentary (16.2%) and female reproductive (10%). The overall survival were significantly higher for cases involving the female reproductive system, followed by the respiratory and alimentary systems (P = 0.016). The median overall survival were worse in males than females for cases involving the respiratory system (22.4 vs. 31.8 months, P = 0.044). Multivariate analysis showed that age ≧ 65, more advanced T and N categories were independent unfavorable prognostic factors of overall survival in ASC. ASC histology is an independent unfavorable prognostic factor compared with AC and SCC.
ASC at an old age and more advanced T and N categories were found to be associated with a poor prognosis.
腺鳞癌（ASC）是一种累及多个器官的罕见疾病，但目前尚无基于大规模人群的不同器官ASC的比较研究。
利用台湾癌症登记处（TCR）的数据，计算并比较了2003年1月1日至2010年12月31日在台湾诊断的各类器官ASC的发病率和总生存率。将各个器官分类并分为三个不同系统：女性生殖系统、呼吸系统和消化系统。还对30850例在ASC常见器官中被诊断为ASC、腺癌（AC）或鳞状细胞癌（SCC）的患者进行了生存分析比较。
在研究期间，台湾共诊断出576例ASC病例。最常见的原发系统是呼吸系统（73.8%），其次是消化系统（16.2%）和女性生殖系统（10%）。女性生殖系统受累病例的总生存率显著更高，其次是呼吸系统和消化系统（P = 0.016）。呼吸系统受累病例中，男性的中位总生存期比女性差（22.4个月对31.8个月，P = 0.044）。多因素分析显示，年龄≥65岁、T和N分期更晚是ASC总生存的独立不良预后因素。与AC和SCC相比，ASC组织学是独立的不良预后因素。
老年ASC以及T和N分期更晚与预后不良相关。
