用稀释聚维酮碘/二甲基亚砜制剂治疗化疗相关性甲沟炎。
Chemotherapy-associated paronychia treated with a dilute povidone-iodine/dimethylsulfoxide preparation.
作者信息
Capriotti Kara, Capriotti Joseph A
机构信息
ALC Therapeutics, LLC, Springhouse, PA, USA ; Bryn Mawr Skin and Cancer Institute, Rosemont, PA, USA.
ALC Therapeutics, LLC, Springhouse, PA, USA ; Plessen Ophthalmology Consultants, Christiansted, VI, USA.
出版信息
Clin Cosmet Investig Dermatol. 2015 Sep 21;8:489-91. doi: 10.2147/CCID.S90542. eCollection 2015.
BACKGROUND
Nail changes associated with chemotherapy in general, and particularly with taxane and epidermal growth factor receptor inhibitor-based regimens, are common presentations in our clinical population. Currently, there are no consensuses about therapies supported by clinical trials nor are there any US Food and Drug Administration-approved treatments for this indication.
FINDINGS
A 42-year-old woman with stage 2A breast cancer presented to our clinic with chemotherapy-induced paronychia. Symptoms were severe enough that cessation of chemotherapy was being considered. The patient's chemotherapy regimen included doxorubicin, cyclophosphamide, and docetaxel.
CONCLUSION
The topical povidone-iodine/dimethylsulfoxide system is very effective in alleviating the signs and symptoms of severe paronychia associated with chemotherapy. This novel combination warrants further investigation in randomized, controlled trials to further elucidate its clinical utility.
背景
一般而言，与化疗相关的指甲改变，尤其是与基于紫杉烷和表皮生长因子受体抑制剂的治疗方案相关的指甲改变，在我们的临床人群中很常见。目前，对于临床试验支持的治疗方法尚无共识，美国食品药品监督管理局也未批准针对该适应症的任何治疗方法。
研究结果
一名42岁的2A期乳腺癌女性因化疗引起的甲沟炎前来我们诊所就诊。症状严重到足以考虑停止化疗。患者的化疗方案包括多柔比星、环磷酰胺和多西他赛。
结论
局部聚维酮碘/二甲基亚砜系统在缓解与化疗相关的严重甲沟炎的体征和症状方面非常有效。这种新的组合值得在随机对照试验中进一步研究，以进一步阐明其临床效用。
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