Chekuri Lakshminarayana, Thapa Purushottam B, Turturro Carolyn L, Mittal Dinesh, Messias Erick
Department of Applied Gerontology, University of North Texas, Denton (Dr Chekuri); Department of Psychiatry, University of Arkansas for Medical Sciences, Little Rock (Drs Chekuri, Thapa, Mittal, and Messias); Department of Psychiatry, Arkansas State Hospital, Little Rock (Dr Thapa); Gerontology Program, School of Social Work, University of Arkansas at Little Rock (Dr Turturro); and Veterans Administration South Central (VISN 16) Mental Illness Research, Education, and Clinical Center, Central Arkansas Veterans Healthcare System, North Little Rock, Arkansas (Dr Mittal).
Prim Care Companion CNS Disord. 2015 Apr 30;17(2). doi: 10.4088/PCC.14m01726. eCollection 2015.
To describe the prevalence of vitamin D deficiency in psychiatric inpatients with serious mental illness. Associated clinical and sociodemographic factors are also explored.
Data were collected using a retrospective review of medical records. Eligible subjects were individuals aged ≥ 18 years who were consecutively newly admitted to an adult inpatient teaching unit of a state psychiatric hospital from July 2012 through August 2013. The main outcome measure was prevalence rate of vitamin D deficiency in the target population. Vitamin D deficiency was defined as a level < 20 ng/mL. Psychiatric diagnoses were established using DSM-IV-TR criteria.
Of 85 subjects, approximately two-thirds (67%) had a vitamin D level < 20 ng/mL. The mean vitamin D level was 18.4 ng/mL. Among the sociodemographic and clinical factors analyzed, only total serum protein (odds ratio = 0.33; CI, 0.12-0.88; P < .05) was associated with vitamin D deficiency.
The high prevalence of vitamin D deficiency with all the attendant physical and mental health burdens in vulnerable populations such as individuals with serious mental illness requires further large research studies. In the meantime, it seems prudent to institute routine screening for vitamin D deficiency in individuals with mental illness, especially those who are hospitalized.
描述患有严重精神疾病的精神病住院患者维生素D缺乏症的患病率。同时探究相关的临床和社会人口学因素。
通过回顾病历收集数据。符合条件的受试者为2012年7月至2013年8月期间连续新入住一家州立精神病医院成人住院教学病房、年龄≥18岁的个体。主要结局指标是目标人群中维生素D缺乏症的患病率。维生素D缺乏定义为水平<20 ng/mL。使用DSM-IV-TR标准进行精神疾病诊断。
85名受试者中，约三分之二（67%）的维生素D水平<20 ng/mL。维生素D平均水平为18.4 ng/mL。在分析的社会人口学和临床因素中，只有总血清蛋白（比值比=0.33；可信区间，0.12 - 0.88；P<.05）与维生素D缺乏有关。
在严重精神疾病患者等弱势群体中，维生素D缺乏症的高患病率以及随之而来的所有身心健康负担，需要进一步开展大型研究。与此同时，对患有精神疾病的个体，尤其是住院患者进行维生素D缺乏症的常规筛查似乎是谨慎之举。
