Schjørring Olav L, Carlsson Rune, Simonsen Ulf
Department of Biomedicine, Aarhus University, DK-8000, Aarhus C, Denmark.
Department of Pulmonary and Cardiovascular Pharmacology, Aarhus University, DK-8000, Aarhus C, Denmark.
Methods Mol Biol. 2015;1339:277-95. doi: 10.1007/978-1-4939-2929-0_19.
Small arteries play an important role in regulation of peripheral resistance and organ perfusion. Here we describe a series of methods allowing measurements in pressurized segments of small arteries from the systemic and coronary circulation of mice as well as other species. The pressure myography techniques described include measurements of wall structure, wall stress, strain, and myogenic tone. The pressurized perfused small arteries also allow evaluation of responses to increases in pressure, flow, and drugs, where the main readout is changes in vascular diameter.
小动脉在调节外周阻力和器官灌注方面发挥着重要作用。在此，我们描述了一系列方法，可用于测量来自小鼠以及其他物种的体循环和冠状动脉循环中小动脉的加压节段。所描述的压力肌动描记术技术包括对血管壁结构、壁应力、应变和肌源性张力的测量。加压灌注的小动脉还可用于评估对压力、流量和药物增加的反应，其中主要的测量指标是血管直径的变化。
