McArthur J C, Marek K, Pestronk A, McArthur J, Peroutka S J
Department of Neurology, Johns Hopkins Hospital, Baltimore, MD.
Neurology. 1989 Feb;39(2 Pt 1):284-6. doi: 10.1212/wnl.39.2.284.
Twenty-four patients with classic migraine attacks were treated with either nifedipine or placebo for up to 12 weeks. No significant differences were observed between the nifedipine (2.1 +/- 0.2) and placebo (2.3 +/- 0.2) treatment groups in the monthly frequency of headaches. However, the incidence of side effects was significantly greater (p less than 0.001) in the nifedipine (54% of patients) than in the placebo (8% of patients) treatment groups.
24名患有典型偏头痛发作的患者接受了硝苯地平或安慰剂治疗，为期长达12周。硝苯地平治疗组（2.1±0.2）和安慰剂治疗组（2.3±0.2）在每月头痛频率方面未观察到显著差异。然而，硝苯地平治疗组（54%的患者）的副作用发生率显著高于安慰剂治疗组（8%的患者）（p<0.001）。
