Xie Pu, Wang Tie-jie, Yin Guo, Yan Yan, Xiao Li-he, Li Qing, Bi Kai-shun
School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, People's Republic of China.
Shenzhen Institute for Drug Control, Shenzhen, 518057, People's Republic of China.
J Mol Neurosci. 2016 Jan;58(1):93-101. doi: 10.1007/s12031-015-0655-x. Epub 2015 Oct 7.
Hair analysis is with the advantage of non-invasive collection and long surveillance window. The present study employed a sensitive and reliable liquid chromatography coupled with ion trap-time of flight mass spectrometry method to study the metabonomic characters in the hair of 58 heroin abusers and 72 non-heroin abusers. Results indicated that certain endogenous metabolites, such as sorbitol and cortisol, were accelerated, and the level of arachidonic acid, glutathione, linoleic acid, and myristic acid was decreased in hair of heroin abusers. The metabonomic study is helpful for further understanding of heroin addiction and clinical diagnosis.
毛发分析具有非侵入性采集和较长监测窗口期的优势。本研究采用灵敏且可靠的液相色谱-离子阱-飞行时间质谱联用方法，研究了58名海洛因滥用者和72名非海洛因滥用者毛发中的代谢组学特征。结果表明，海洛因滥用者毛发中的某些内源性代谢物，如山梨醇和皮质醇，含量升高，而花生四烯酸、谷胱甘肽、亚油酸和肉豆蔻酸的水平降低。代谢组学研究有助于进一步了解海洛因成瘾及临床诊断。
