光触发化学放大以加速从聚合物颗粒中的降解和释放。
Light-triggered chemical amplification to accelerate degradation and release from polymeric particles.
作者信息
Olejniczak Jason, Nguyen Huu Viet Anh, Lux Jacques, Grossman Madeleine, He Sha, Almutairi Adah
机构信息
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA.
Department of NanoEngineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA.
出版信息
Chem Commun (Camb). 2015 Dec 11;51(95):16980-3. doi: 10.1039/c5cc06143a.
We describe a means of chemical amplification to accelerate triggered degradation of a polymer and particles composed thereof. We designed a light-degradable copolymer containing carboxylic acids masked by photolabile groups and ketals. Photolysis allows the unmasked acidic groups in the polymer backbone to accelerate ketal hydrolysis even at neutral pH.
我们描述了一种化学放大方法，以加速聚合物及其组成颗粒的触发降解。我们设计了一种光降解共聚物，其含有被光不稳定基团和缩酮掩盖的羧酸。光解使聚合物主链中未被掩盖的酸性基团即使在中性pH值下也能加速缩酮水解。
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