非缺血性心肌病患者右心室功能的性别差异
Gender differences in right ventricular function in patients with non-ischaemic cardiomyopathy.
作者信息
Martínez-Sellés M, Pérez-David E, Yotti R, Jiménez-Borreguero J, Loughlin G, Gallego L, Ayesta A, Olivera M J, Bermejo J, Fernández-Avilés F
机构信息
Cardiology Department, Servicio de Cardiología, Hospital General Universitario Gregorio Marañón, and Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense de Madrid, and Universidad Europea de Madrid, Calle Dr. Esquerdo 46, 28007, Madrid, Spain.
Cardiology Department, Hospital General Universitario Gregorio Marañón, and Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
出版信息
Neth Heart J. 2015 Dec;23(12):578-84. doi: 10.1007/s12471-015-0753-y.
AIM
To evaluate sex-related differences in right ventricular (RV) function, assessed with cardiac magnetic resonance imaging, in patients with stable non-ischaemic dilated cardiomyopathy.
METHODS
Prospective multicentre study. We included 71 patients (38 men) and 14 healthy volunteers.
RESULTS
Mean age was 60.9 ± 12.2 years. Men presented higher levels of haemoglobin and white blood cell counts than women, and performed better in cardiopulmonary stress testing. A total of 24 patients (12 women) presented severe left ventricular (LV) systolic dysfunction, 32 (13 female) moderate and 15 (8 women) mild LV systolic dysfunction. In the group with severe LV systolic dysfunction, average right ventricular ejection fraction (RVEF) was normal in women (52 ± 4 %), whereas it was reduced in men (39 ± 3 %) p = 0.035. Only one woman (8 %) had severe RV systolic dysfunction (RVEF < 35 %) compared with 6 men (50 %) p < 0.001. In patients with moderate and mild LV dysfunction , the mean RVEF was normal in both men and women. In the 14 healthy volunteers, the lowest value of RVEF was 48 % and mean RVEF was normal in women (56 ± 2 %) and in men (51 ± 1 %), p = 0.08.
CONCLUSIONS
In patients with dilated cardiomyopathy, RV systolic dysfunction is found mainly in male patients with severe LV systolic dysfunction.
目的
采用心脏磁共振成像评估稳定型非缺血性扩张型心肌病患者右心室（RV）功能的性别差异。
方法
前瞻性多中心研究。我们纳入了71例患者（38例男性）和14名健康志愿者。
结果
平均年龄为60.9±12.2岁。男性的血红蛋白和白细胞计数水平高于女性，且在心肺应激试验中的表现更好。共有24例患者（12例女性）出现严重左心室（LV）收缩功能障碍，32例（13例女性）为中度，15例（8例女性）为轻度LV收缩功能障碍。在严重LV收缩功能障碍组中，女性的平均右心室射血分数（RVEF）正常（52±4%），而男性则降低（39±3%），p=0.035。只有1名女性（8%）出现严重RV收缩功能障碍（RVEF<35%），而男性有6名（50%），p<0.001。在中度和轻度LV功能障碍患者中，男性和女性的平均RVEF均正常。在14名健康志愿者中，RVEF的最低值为48%，女性（56±2%）和男性（51±1%）的平均RVEF正常，p=0.08。
结论
在扩张型心肌病患者中，RV收缩功能障碍主要见于严重LV收缩功能障碍的男性患者。
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