Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, GRB-800, Boston, MA 02114, USA.
Cardiol Clin. 2012 May;30(2):271-82. doi: 10.1016/j.ccl.2012.03.011.
Right ventricular physiology is characterized by its close relationship with the pulmonary circuit. The right ventricle can accommodate significant changes in preload, but is highly sensitive to increases in afterload. Progressive dilatation and dysfunction can initiate a cycle of oxygen supply-demand mismatch that ultimately leads to right ventricular failure. Echocardiography and cardiac magnetic resonance imaging are the primary modalities used for non-invasive assessment of right ventricular function. The management of right ventricular failure centers on the optimization of preload, afterload and contractility. Few targeted therapies exist, although novel agents have shown promise in early studies.
右心室生理学的特点是与肺循环密切相关。右心室可以适应前负荷的显著变化，但对后负荷的增加非常敏感。进行性扩张和功能障碍会引发氧供需失衡的循环，最终导致右心衰竭。超声心动图和心脏磁共振成像是非侵入性评估右心室功能的主要方式。右心衰竭的治疗重点在于优化前负荷、后负荷和收缩力。虽然一些新型药物在早期研究中显示出了希望，但目前还没有针对右心衰竭的靶向治疗药物。
