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炎症性肠病中的痔疮和肛裂

Hemorrhoids and anal fissures in inflammatory bowel disease.

作者信息

D'Ugo S, Stasi E, Gaspari A L, Sileri P

机构信息

General Surgery Unit, University Hospital Tor Vergata, Rome, Italy -

出版信息

Minerva Gastroenterol Dietol. 2015 Dec;61(4):223-33. Epub 2015 Oct 7.

Abstract

Perianal disease is a common complication of inflammatory bowel disease (IBD). It includes different conditions from more severe and potentially disabling ones, such as abscesses and fistulas, to more benign conditions such as hemorrhoids, skin tags and fissures. Most literature has been focused on anal sepsis and fistulae, as they carry the majority of disease burden and often alter the natural course of the disease. Hemorrhoids and anal fissures in patients with IBD have been overlooked, although they can represent a challenging problem. The management of hemorrhoids and fissures in IBD patients may be difficult and may significantly differ compared to the non-affected population. Historically surgery was firmly obstructed, and hemorrhoidectomy or sphincterotomy in patients with associated diagnosis of IBD was considered harmful, although literature data is scant and based on small series. Various authors reported an incidence of postoperative complications higher in IBD than in the general populations, with potential severe events. Considering that a spontaneous healing is possible, the first line management should be a medical therapy. In patients non-responding to conservative measures it is possible a judicious choice of surgical options on a highly selective basis; this can lead to acceptable results, but the risk of possible complications needs to be considered. In this review it is analyzed the current literature on the incidence, symptoms and treatment options of hemorrhoids and anal fissures in patients with Crohn's disease and ulcerative colitis.

摘要

肛周疾病是炎症性肠病(IBD)的常见并发症。它包括从较为严重且可能导致残疾的不同病症,如脓肿和肛瘘,到较为良性的病症,如痔疮、皮赘和肛裂。大多数文献都聚焦于肛门脓毒症和肛瘘,因为它们承担了大部分疾病负担,且常常改变疾病的自然进程。IBD患者的痔疮和肛裂一直被忽视,尽管它们可能是一个具有挑战性的问题。IBD患者痔疮和肛裂的治疗可能很困难,且与未患病人群相比可能有显著差异。从历史上看,手术受到坚决阻碍,IBD相关诊断患者的痔切除术或括约肌切开术被认为是有害的,尽管文献数据匮乏且基于小样本系列研究。多位作者报告IBD患者术后并发症的发生率高于普通人群,且可能出现严重事件。鉴于有可能自愈,一线治疗应是药物治疗。对于对保守措施无反应的患者,在高度选择性的基础上明智地选择手术方案是可行的;这可能会带来可接受的结果,但需要考虑可能出现并发症的风险。本综述分析了关于克罗恩病和溃疡性结肠炎患者痔疮和肛裂的发病率、症状及治疗选择的当前文献。

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