Yan Hua, Lu Xiaolan, Gao Yanqiong, Luo Jinyan
Department of Gastroenterology, Shanxi Provincial People's Hospital, Xi'an 710068, China.
Department of Digestive, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Zhonghua Gan Zang Bing Za Zhi. 2015 Aug;23(8):622-7. doi: 10.3760/cma.j.issn.1007-3418.2015.08.013.
To describe the incidence and related risk factors of fatty liver disease in the general population of Northwest China.
The study was a cross-sectional survey with multiplestage stratified cluster and random sampling. All participants were 18 years or older and resided in northwest provinces of China.Demographic and behavioral data was gathered by questionnaire.Clinical data such as height, body weight, waist circumference, biochemical function (standard tests) and liver status (ultrasonographic examination) were also collected.
Among the 2 300 total study participants, 1 523 were habitual drinkers (total drinking rate: 66.2%). This population of drinkers was composed almost exclusively of males. There were 201 cases of alcoholic liver disease (total prevalence:8.7%), represented by mild alcoholic injury (prevalence: 4.2%), alcoholic fatty liver (3.8%), alcoholic hepatitis (0.5%), and alcoholic cirrhosis (0.3%).When examined according to provinces of residence, the prevalence of alcoholic liver disease followed this pattern: Shaanxi (14.0%), Gansu (8.6%), and Xinjiang autonomous region (5.0%). Of the total 337 cases of nonalcoholic fatty liver disease (total prevalence: 14.7%), the prevalence by province was: Shaanxi (18.5%), Gansu (10.3%), and Xinjiang autonomous region (16.6%). Individuals with alcoholic liver disease had significantly higher mean age (years), body weight, body mass index (BMI), waist circumference, average daily alcohol intake, and level of aspartate aminotransferase (AST), and alanine aminotraasferase (ALT) (vs. Those with no liver disease, P less than 0.05). Individuals with nonalcoholic fatty liver disease had significantly higher mean age (years), height, body weight, BMI, waist circumference, level of AST and ALT, and presence of obesity, abdominal obesity, hyperlipidemia, diabetes mellitus and hypertension (vs. Those with no liver disease, P less than 0.05). Multiple logistic regression demonstrated that alcoholic liver disease was closely related to age, sex, and average daily alcohol intake. The prevalence of nonalcoholic fatty liver disease was positively correlated to age, female sex, hyperlipidemia, diabetes mellitus, and BMI.
The drinking-rate and prevalence of fatty liver disease is high in Northwest China, but the most prevalent type is nonalcoholic fatty liver disease.Fatty liver disease is closely related to age, sex, average daily alcohol intake, hyperlipidemia, diabetes mellitus, and BMI.
描述中国西北地区普通人群中脂肪肝疾病的发病率及相关危险因素。
本研究为多阶段分层整群随机抽样的横断面调查。所有参与者年龄在18岁及以上，居住在中国西北省份。通过问卷调查收集人口统计学和行为学数据。还收集了身高、体重、腰围、生化功能（标准检测）和肝脏状况（超声检查）等临床数据。
在总共2300名研究参与者中，有1523名是习惯性饮酒者（总饮酒率：66.2%）。这一饮酒人群几乎全为男性。有201例酒精性肝病（总患病率：8.7%），以轻度酒精性损伤（患病率：4.2%）、酒精性脂肪肝（3.8%）、酒精性肝炎（0.5%）和酒精性肝硬化（0.3%）为代表。按居住省份检查时，酒精性肝病的患病率呈现以下模式：陕西（14.0%）、甘肃（8.6%）和新疆维吾尔自治区（5.0%）。在总共337例非酒精性脂肪肝病例中（总患病率：14.7%），按省份划分的患病率为：陕西（18.5%）、甘肃（10.3%）和新疆维吾尔自治区（16.6%）。酒精性肝病患者的平均年龄（岁）、体重、体重指数（BMI）、腰围、平均每日酒精摄入量以及天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）水平显著更高（与无肝病者相比，P<0.05）。非酒精性脂肪肝患者的平均年龄（岁）、身高、体重、BMI、腰围、AST和ALT水平以及肥胖、腹型肥胖、高脂血症、糖尿病和高血压的患病率显著更高（与无肝病者相比，P<0.05）。多因素logistic回归显示，酒精性肝病与年龄、性别和平均每日酒精摄入量密切相关。非酒精性脂肪肝的患病率与年龄、女性、高脂血症、糖尿病和BMI呈正相关。
中国西北地区饮酒率和脂肪肝患病率较高，但最常见的类型是非酒精性脂肪肝。脂肪肝疾病与年龄、性别、平均每日酒精摄入量、高脂血症、糖尿病和BMI密切相关。
