Department of Fundamental and Community Nursing, School of Nursing, Nanjing Medical University, 101 Longmian Avenue, Nanjing, 211166, Jiangsu, China.
Shanghai Cancer Institute, Shanghai, 200032, China.
BMC Public Health. 2023 Jul 1;23(1):1276. doi: 10.1186/s12889-023-15645-4.
This meta-analysis aimed to explore the epidemiological characteristics of alcohol-related liver disease (ALD) in China.
Studies published between January 2000 and January 2023 were searched from 3 databases in English and 3 databases in Chinese. DerSimonian-Laird's random-effects model was adopted to calculate the pooled prevalence.
A total of 21 studies were included. The pooled prevalence of ALD was 4.8% (95% CI, 3.6%-6.2%) in the general population, 9.3% (95% CI, 4.4%-16.0%) in males, and 2.0% (95% CI, 0.0%-6.7%) in females. The prevalence was the highest in western China (5.0% [95% CI, 3.3%-6.9%]) and the lowest in central China (4.4% [95% CI, 4.0%-4.8%]). The prevalence among people with different drinking histories (less than 5 years, 5 to 10 years, and over 10 years) was 0.9% (95% CI, 0.2%-1.9%), 4.6% (95% CI, 3.0%-6.5%), and 9.9% (95% CI, 6.5%-14.0%), respectively. The prevalence in 1999-2004 was 4.7% (95% CI, 3.0%-6.7%) and then changed from 4.3% (95% CI, 3.5%-5.3%) in 2005-2010 to 6.7% (95% CI, 5.3%-8.3%) in 2011-2016.
The prevalence of ALD in China has increased in recent decades, with population-related variations. Targeted public health strategies are needed, especially in high-risk groups, such as male with long-term alcohol drinking.
The registration number on PROSPERO is CRD42021269365.
本荟萃分析旨在探讨中国酒精性肝病（ALD）的流行病学特征。
检索了 2000 年 1 月至 2023 年 1 月期间发表的英文 3 个数据库和中文 3 个数据库中的研究。采用 DerSimonian-Laird 的随机效应模型计算合并患病率。
共纳入 21 项研究。普通人群中 ALD 的总患病率为 4.8%（95%CI，3.6%-6.2%），男性为 9.3%（95%CI，4.4%-16.0%），女性为 2.0%（95%CI，0.0%-6.7%）。西部地区的患病率最高（5.0%[95%CI，3.3%-6.9%]），中部地区的患病率最低（4.4%[95%CI，4.0%-4.8%]）。不同饮酒史（<5 年、5-10 年、>10 年）人群的患病率分别为 0.9%（95%CI，0.2%-1.9%）、4.6%（95%CI，3.0%-6.5%）和 9.9%（95%CI，6.5%-14.0%）。1999-2004 年的患病率为 4.7%（95%CI，3.0%-6.7%），然后从 2005-2010 年的 4.3%（95%CI，3.5%-5.3%）变为 2011-2016 年的 6.7%（95%CI，5.3%-8.3%）。
中国近几十年来 ALD 的患病率呈上升趋势，存在人群相关的变化。需要采取有针对性的公共卫生策略，特别是针对长期饮酒的男性等高危人群。
PROSPERO 注册号为 CRD42021269365。
