Angelini P
Department of Cardiology, Texas Heart Institute, Houston 77225.
Am Heart J. 1989 Feb;117(2):418-34. doi: 10.1016/0002-8703(89)90789-8.
Results of a comprehensive survey of the literature concerning coronary artery anatomy, embryology, and pathophysiology show the lack of an adequate definition of normal coronary arteries. To fill this gap, the present review considers the available data concerning the embryogenesis of the coronary arteries and proposes a new definition of normality that refers to essential anatomic features. The concepts of normal variant versus anomaly are introduced, based on a statistical definition of the normal range (99% of the presentations observed in a normal, unselected population). Coronary anomalies are defined as those patterns found in less than 1% of the cases. The wide spectrum of coronary abnormalities is then organized according to a comprehensive classification scheme. For clinical purposes the conceptual difference between anatomic and pathophysiologic anomalies is stressed. The current paucity of experimental studies concerning normal and abnormal embryogenesis of the coronary arteries is found to be the major limitation to an understanding of this subject.
一项关于冠状动脉解剖学、胚胎学和病理生理学的全面文献调查结果显示，目前缺乏对正常冠状动脉的充分定义。为填补这一空白，本综述考虑了有关冠状动脉胚胎发生的现有数据，并提出了一个新的正常定义，该定义涉及基本的解剖特征。基于正常范围的统计定义（在正常、未经过筛选的人群中观察到的99%的表现），引入了正常变异与异常的概念。冠状动脉异常被定义为在不到1%的病例中发现的那些模式。然后根据一个全面的分类方案对广泛的冠状动脉异常进行整理。出于临床目的，强调了解剖学异常和病理生理学异常之间的概念差异。目前关于冠状动脉正常和异常胚胎发生的实验研究匮乏，这被认为是理解该主题的主要限制因素。
