Aylward Lesa L, Seiber James N, Hays Sean M
Summit Toxicology, LLP, Falls Church, VA 22044, USA; National Centre for Environmental Toxicology, University of Queensland, Brisbane, QLD, Australia.
Department of Environmental Toxicology, University of California, Davis, CA 95616, USA.
Regul Toxicol Pharmacol. 2015 Dec;73(3):875-84. doi: 10.1016/j.yrtph.2015.10.002. Epub 2015 Oct 23.
The California Environmental Biomonitoring Program (also known as Biomonitoring California) has been generating human biomonitoring data and releasing it via their website. The current Biomonitoring California program is a collection of smaller studies, targeting specific populations (e.g., fire fighters, breast cancer patients and controls, etc.). In this paper we compare the results from Biomonitoring California with those from the US National Health and Nutrition Examination Survey (NHANES). We also compare California's results with Biomonitoring Equivalents (BEs) for those compounds for which BEs exist. In general, the results from California are consistent with the biomonitoring levels found across the US via NHANES. A few notable exceptions are levels of flame retardants amongst fire fighters in California, which are higher than observed in NHANES and some persistent organic chemicals amongst a study of breast cancer patients and controls in California which are higher than in the overall adult population in NHANES. The higher levels amongst fire fighters may be a result of fire fighters being exposed to higher levels of flame retardants while fighting fires. The higher levels of the persistent organics amongst breast cancer patients is likely due to this population being older than the mean age in NHANES. Comparisons to BEs indicate that biomonitoring levels in California are all consistently below levels of concern as established by regulatory agencies.
加利福尼亚环境生物监测项目（也称为“加利福尼亚生物监测”）一直在收集人体生物监测数据，并通过其网站予以发布。当前的加利福尼亚生物监测项目是一系列规模较小的研究，针对特定人群（如消防员、乳腺癌患者及其对照等）。在本文中，我们将加利福尼亚生物监测项目的结果与美国国家健康与营养检查调查（NHANES）的结果进行了比较。我们还将加利福尼亚的结果与存在生物监测等效值（BEs）的那些化合物的生物监测等效值进行了比较。总体而言，加利福尼亚的结果与通过NHANES在美国各地发现的生物监测水平一致。一些值得注意的例外情况是，加利福尼亚消防员体内的阻燃剂水平高于NHANES中的观测值，以及在加利福尼亚乳腺癌患者及其对照的一项研究中，一些持久性有机化学品的水平高于NHANES中的成年总体人群。消防员体内较高的水平可能是由于他们在灭火时接触到更高水平的阻燃剂。乳腺癌患者体内持久性有机物水平较高可能是因为该人群的年龄高于NHANES中的平均年龄。与生物监测等效值的比较表明，加利福尼亚的生物监测水平始终低于监管机构确定的关注水平。
