Frisdal Eric, Le Goff Wilfried
INSERM; UMR_S1166; Team 4 ; Paris, France ; Université Pierre et Marie Curie-Paris6 ; Paris, France ; Institute of Cardiometabolism and Nutrition (ICAN); Pitié-Salpêtrière Hospital ; Paris, France.
Adipocyte. 2015 Mar 9;4(4):315-8. doi: 10.1080/21623945.2015.1023491. eCollection 2015 Oct-Dec.
The importance of ATP-Binding Cassette G1 (ABCG1) transporter in obesity was recently brought to light by recent findings uncovering its key role in adipogenesis with physiopathological consequences in human obesity. Thus, silencing of ABCG1 expression using an RNAi approach allows inhibition of adipocyte differentiation and maturation leading to reduction of fat mass growth in vivo in mice. Studies of ABCG1 in obese subjects validated its deleterious role in the context of obesity, suggesting that adipose tissue ABCG1 could be a potential therapeutic target in obese patients. Here, we discuss the potential feasibility of such strategy and provide a brief overview of critical issues to be considered.
最近，ATP结合盒转运体G1（ABCG1）转运蛋白在肥胖症中的重要性因一些新发现而得以揭示，这些发现揭示了其在脂肪生成中的关键作用以及对人类肥胖症的生理病理影响。因此，采用RNA干扰方法沉默ABCG1的表达能够抑制脂肪细胞的分化和成熟，从而减少小鼠体内脂肪量的增长。对肥胖受试者中ABCG1的研究证实了其在肥胖症背景下的有害作用，这表明脂肪组织中的ABCG1可能是肥胖患者潜在的治疗靶点。在此，我们讨论这种策略的潜在可行性，并简要概述一些需要考虑的关键问题。
