丙二醛作为心理障碍中氧化应激生物标志物的可靠性。
Reliability of malondialdehyde as a biomarker of oxidative stress in psychological disorders.
作者信息
Khoubnasabjafari Maryam, Ansarin Khalil, Jouyban Abolghasem
机构信息
Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Bioimpacts. 2015;5(3):123-7. doi: 10.15171/bi.2015.20. Epub 2015 Jul 26.
Despite very wide variations of malondialdehyde (MDA) concentrations in biological samples, it is still used as a biomarker of oxidative stress in clinical investigations. In the current perspective study, we aimed to summarize a number of critical analytical points for determination of MDA. Technical problems and controversial findings in healthy people and some psychiatric disorders reveal that the reliability of MDA as a biomarker of oxidative stress n eeds to be re-evaluated by experts.
尽管生物样本中丙二醛（MDA）浓度存在很大差异，但它在临床研究中仍被用作氧化应激的生物标志物。在当前的前瞻性研究中，我们旨在总结一些测定MDA的关键分析要点。健康人群和一些精神疾病中的技术问题及有争议的研究结果表明，MDA作为氧化应激生物标志物的可靠性需要专家重新评估。
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