儿童的有毒环境暴露与肾脏健康
Toxic environmental exposures and kidney health in children.
作者信息
Weidemann Darcy K, Weaver Virginia M, Fadrowski Jeffrey J
机构信息
Division of Pediatric Nephrology, Children's Mercy Hospital, 2401 Gillham Rd, Kansas City, MO, 64108, USA.
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
出版信息
Pediatr Nephrol. 2016 Nov;31(11):2043-54. doi: 10.1007/s00467-015-3222-3. Epub 2015 Oct 12.
Abstract
High-level exposures to a number of agents are known to have direct nephrotoxic effects in children. A growing body of literature supports the hypothesis that chronic, relatively low-level exposure to various nephrotoxicants may also increase the risk for chronic kidney disease (CKD) or accelerate its progression. In this review we highlight several environmental nephrotoxicants and their association with CKD in children and adolescents. We also discuss unique epidemiological challenges in the use of kidney biomarkers in environmental nephrotoxicology.
摘要
已知儿童接触多种高剂量的物质会产生直接的肾毒性作用。越来越多的文献支持这样一种假说，即长期、相对低剂量接触各种肾毒物也可能增加患慢性肾脏病（CKD）的风险或加速其进展。在本综述中，我们重点介绍了几种环境肾毒物及其与儿童和青少年CKD的关联。我们还讨论了在环境肾毒理学中使用肾脏生物标志物时所面临的独特流行病学挑战。
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