Department of Family Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Department of Family Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Int J Med Sci. 2021 Jan 1;18(5):1121-1129. doi: 10.7150/ijms.51594. eCollection 2021.
Chronic kidney disease (CKD) is a global public health problem associated with high rates of morbidity and mortality due to end-stage renal disease and cardiovascular disease. Safe and effective medications to reverse or stabilize renal function in patients with CKD are lacking, and hence it is important to identify modifiable risk factors associated with worsening kidney function. Environmental pollutants, including metals, air pollutant, phthalate and melamine can potentially increase the risk of CKD or accelerate its progression. In this review, we discuss the epidemiological evidence for the association between environmental pollution and kidney disease, including heavy metals, air pollution and other environmental nephrotoxicants in the general population.
慢性肾脏病（CKD）是一个全球性的公共卫生问题，由于终末期肾病和心血管疾病，其发病率和死亡率都很高。目前缺乏能够逆转或稳定 CKD 患者肾功能的安全有效的药物，因此，确定与肾功能恶化相关的可改变的危险因素非常重要。环境污染物，包括金属、空气污染物、邻苯二甲酸酯和三聚氰胺，可能会增加 CKD 的风险或加速其进展。在这篇综述中，我们讨论了环境污染与肾脏病之间的关联的流行病学证据，包括一般人群中的重金属、空气污染和其他环境肾毒物。
