木脂素内酯（-）-扁柏素的全合成

Total Synthesis of Lignan Lactone (-)-Hinokinin.

作者信息

Zhou Qi-Long, Wang Hui-Jing, Tang Pei, Song Hao, Qin Yong

机构信息

Innovative Drug Research Centre, Chongqing University, Chongqing, 401331, China.

Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.

出版信息

Nat Prod Bioprospect. 2015 Oct;5(5):255-61. doi: 10.1007/s13659-015-0073-3. Epub 2015 Oct 12.

DOI:10.1007/s13659-015-0073-3

PMID:26458924

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4607678/

Abstract

This research paper is aimed at studying the total synthesis of pharmacologically active lignan (-)-hinokinin. The synthesis features a three-step cascade reaction involving highly stereoselective Michael addition, anion-oxidative hydroxylation, and oxygen anion cyclization to construct the pivotal butyrolactonimidate intermediate.

摘要

本研究论文旨在研究具有药理活性的木脂素（-）-日扁柏素的全合成。该合成的特点是三步串联反应，包括高度立体选择性的迈克尔加成、阴离子氧化羟基化和氧阴离子环化，以构建关键的丁内酯亚胺中间体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0245/4607678/a2d652caa314/13659_2015_73_Fig1_HTML.jpg

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木脂素内酯（-）-扁柏素的全合成

Total Synthesis of Lignan Lactone (-)-Hinokinin.

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木脂素内酯（-）-扁柏素的全合成

Total Synthesis of Lignan Lactone (-)-Hinokinin.

作者信息

机构信息

出版信息

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