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从[来源处]提取的木脂素的药用特性：当前进展

Medicinal Attributes of Lignans Extracted from : Current Developments.

作者信息

Godoy de Lima Regiane, Barros Maria Teresa, da Silva Laurentiz Rosangela

机构信息

LAQV, REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa 2829-516 Caparica Portugal), Tel. (+351) 212948361.

Department of Physics and Chemistry São Paulo State University Av. Brasil 56 15380-000 Ilha Solteira-SP Brasil.

出版信息

ChemistryOpen. 2018 Feb 2;7(2):180-191. doi: 10.1002/open.201700182. eCollection 2018 Feb.

DOI:10.1002/open.201700182
PMID:29435403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5795757/
Abstract

Lignans are a large class of natural products that have been isolated from many plants. They reveal diverse biological activities, especially antiviral and antitumor properties. From , lignans of several classes can be isolated from the roots, rhizomes, stems, leaves, seeds, and fruits. Among its various chemical constituents, (-)-cubebin and (-)-hinokinin are found in significant quantities. Although they have been known for some time, during the last few decades their biological properties have been studied by several research groups. The cubebins have been identified as a lactol monomer and dimers as a mixture of diastereoisomers. Recently, their structural characterization and the synthesis of the possible structures have led to the correction of some earlier structural proposals. This review describes the more recent developments in the study of the medicinal attributes of cubebin and hinokinin extracted from and the synthesis and biological testing of some analogues.

摘要

木脂素是一类从多种植物中分离出来的天然产物。它们具有多种生物活性，尤其是抗病毒和抗肿瘤特性。从[具体植物名称未给出]中，可以从根、根茎、茎、叶、种子和果实中分离出几类木脂素。在其各种化学成分中，（-）-荜澄茄素和（-）-扁柏脂素含量较高。尽管它们已为人所知一段时间，但在过去几十年里，几个研究小组对它们的生物学特性进行了研究。荜澄茄素已被鉴定为一种内酯单体，而二聚体则是一种非对映异构体混合物。最近，它们的结构表征以及可能结构的合成导致了一些早期结构提议的修正。本综述描述了从[具体植物名称未给出]中提取的荜澄茄素和扁柏脂素药用特性研究的最新进展，以及一些类似物的合成和生物学测试。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d617/5795757/cb648566bae3/OPEN-7-180-g019.jpg
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Total Synthesis of (-)-Bicubebin A, B, (+)-Bicubebin C and Structural Reassignment of (-)-cis-Cubebin.(-)-毕扣扣林 A、B、(+)-毕扣扣林 C 的全合成及 (-)-顺式-毕扣扣林的结构重定。
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In vivo and in silico anti-inflammatory mechanism of action of the semisynthetic (-)-cubebin derivatives (-)-hinokinin and (-)-O-benzylcubebin.
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Recent advances in research on lignans and neolignans.近年来关于木脂素和新木脂素的研究进展。
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