Olson H M, Capen C C
J Natl Cancer Inst. 1977 Feb;58(2):433-7. doi: 10.1093/jnci/58.2.433.
Osteosarcomas were induced in approximately 80% of young New Zealand Black rats by the intratibial inoculation of Moloney murine sarcoma virus from day 1 to day 5 after birth. The neoplasms were composed of a spectrum of well-differentiated to poorly differentiated osteoblasts, osteocytes, and osteoclasts. Budding of C-type viral particles was associated with tumor induction. Compared to rats inoculated on day 1 after birth, rats inoculated at 4 days of age developed consistently more osteoproliferative bone tumors that often were associated with hypercalcemia, increased serum alkaline phosphatase, and elevated urinary hydroxyproline.
通过在出生后第1天至第5天经胫骨接种莫洛尼鼠肉瘤病毒，在约80%的幼年新西兰黑鼠中诱发骨肉瘤。肿瘤由一系列分化良好至分化不良的成骨细胞、骨细胞和破骨细胞组成。C型病毒颗粒的出芽与肿瘤诱导有关。与出生后第1天接种的大鼠相比，4日龄接种的大鼠 consistently 发生更多的骨增殖性骨肿瘤，这些肿瘤常伴有高钙血症、血清碱性磷酸酶升高和尿羟脯氨酸升高。
原文中“consistently”这个词在这里的表述有些奇怪，可能存在拼写错误之类的问题，但按照要求直接翻译了。
