Low Jun How, Ramdas Premdass, Radhakrishnan Ammu Kutty
Rockhampton Base Hospital, Central Queensland, Australia; Division of Pathology, Faculty of Medicine and Health Sciences, International Medical University, Malaysia.
Division of Human Biology, Faculty of Medicine and Health Sciences, International Medical University, Malaysia.
Blood Cells Mol Dis. 2015 Dec;55(4):351-7. doi: 10.1016/j.bcmd.2015.07.017. Epub 2015 Aug 1.
Mesenchymal stem cells (MSCs) have drawn much attention amongst stem cell researchers in the past few decades. The ability of the MSC to differentiate into cells of mesodermal and non-mesodermal origins has made them an attractive approach for cell-based therapy and regenerative medicine. The MSCs have immunosuppressive activities that may have considerable therapeutic values in autoimmune diseases. However, despite the many beneficial effects reported, there is a growing body of evidence, which suggests that MSCs could be a culprit of enhanced tumour growth, metastasis and drug resistance in leukaemia, via some modulatory effects. Many controversies regarding the interactions between MSCs and leukaemia still exist. Furthermore, the role of MSCs in leukemogenesis and its progression remain largely unknown. Hence it is important to understand how the MSCs modulate leukaemia before these cells could be safely used in the treatment of leukaemia patients.
在过去几十年中，间充质干细胞（MSCs）引起了干细胞研究人员的广泛关注。MSCs分化为中胚层和非中胚层来源细胞的能力，使其成为基于细胞的治疗和再生医学的一种有吸引力的方法。MSCs具有免疫抑制活性，这在自身免疫性疾病中可能具有相当大的治疗价值。然而，尽管有许多报道的有益效果，但越来越多的证据表明，MSCs可能通过一些调节作用成为白血病中肿瘤生长、转移和耐药性增强的罪魁祸首。关于MSCs与白血病之间相互作用的许多争议仍然存在。此外，MSCs在白血病发生及其进展中的作用在很大程度上仍然未知。因此，在这些细胞能够安全地用于治疗白血病患者之前，了解MSCs如何调节白血病是很重要的。
