Department of Hematology, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.
Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China.
Hematol Oncol. 2021 Apr;39(2):162-169. doi: 10.1002/hon.2793. Epub 2020 Sep 1.
Mesenchymal stem cells (MSCs) are a subset of multifunctional stem cells with self-renewal and multidirectional differentiation properties that play a pivotal role in tumor progression. MSCs are reported to exert biological functions by secreting specialized vesicles, known as exosomes, with tumor cells. Exosomes participate in material and information exchange between cells and are crucial in multiple physiological and pathological processes. This study provides a comprehensive overview of the roles, mechanisms of action and sources of MSC exosomes in hematological malignancies, and different tumor types.
间充质干细胞（MSCs）是一种具有自我更新和多向分化特性的多功能干细胞亚群，在肿瘤进展中起着关键作用。据报道，MSCs 通过与肿瘤细胞分泌的特殊囊泡（称为外泌体）发挥生物学功能。外泌体参与细胞间的物质和信息交换，在多种生理和病理过程中起着至关重要的作用。本研究全面概述了 MSCs 外泌体在血液系统恶性肿瘤和不同肿瘤类型中的作用、作用机制和来源。
