Department of Medical Laboratory Sciences, School of Paramedicine, Hamadan University of Medical Sciences, Shahid Fahmideh Blvd., The Opposite Side of Mardom Park, Hamadan, 6517838741, Iran.
Hematology Department, School of Allied Medical Science, Iran University of Medical Sciences, Tehran, Iran.
Cell Commun Signal. 2022 Mar 2;20(1):21. doi: 10.1186/s12964-022-00822-6.
Mesenchymal stem/stromal cells (MSCs) are known as the issue in biology because of some unpredictable characteristics in the different microenvironments especially in their bone marrow niche. MSCs are used in the regenerative medicine because of their unique potentials for trans-differentiation, immunomodulation, and paracrine capacity. But, their pathogenic and pro-survival effects in tumors/cancers including hematologic malignancies are indisputable. MSCs and/or their derivatives might be involved in tumor growth, metastasis and drug resistance in the leukemias. One of important relationship is MSCs and hematologic malignancy-derived cells which affects markedly the outcome of disease. The communication between these two cells may be contact-dependent and/or contact-independent. In this review, we studied the crosstalk between MSCs and malignant hematologic cells which results the final feedback either the progression or suppression of blood cell malignancy. Video abstract.
间充质干细胞（MSCs）因其在不同微环境中存在一些不可预测的特性，尤其是在骨髓龛中，被称为生物学上的难题。由于其具有独特的转分化、免疫调节和旁分泌能力，MSCs 被用于再生医学。但是，它们在肿瘤/癌症中的致病和促生存作用，包括血液恶性肿瘤，是不可否认的。MSCs 和/或其衍生物可能参与白血病中的肿瘤生长、转移和耐药性。一个重要的关系是 MSCs 和血液恶性肿瘤衍生细胞之间的相互作用，这显著影响疾病的转归。这两种细胞之间的通讯可能是依赖接触的和/或非接触依赖的。在这篇综述中，我们研究了 MSCs 和恶性血液细胞之间的串扰，导致血细胞恶性肿瘤的进展或抑制的最终反馈。视频摘要。
