Grove B K
Department of Anatomy, University of Umeå, Sweden.
Crit Rev Neurobiol. 1989;4(3):201-34.
The biology of muscle development has gone full circle--from classical embryonic morphology to cell culture and now back to the embryo at the molecular and cellular levels. Recent advances in modern technology have made possible complex in vitro and in vivo biochemical and ultrastructural analyses of myogenesis. This article correlates theories regarding the events and regulatory factors involved in muscle differentiation and fiber-type formation based on findings from the model system of isolated muscle cells in culture with actual in vivo situations.
肌肉发育生物学已经经历了一个完整的循环——从经典的胚胎形态学研究到细胞培养，现在又回到了分子和细胞水平上的胚胎研究。现代技术的最新进展使得对肌生成进行复杂的体外和体内生化及超微结构分析成为可能。本文基于在体外培养的分离肌肉细胞模型系统中的研究结果，将有关肌肉分化和纤维类型形成过程中涉及的事件及调节因子的理论，与实际的体内情况联系起来。
