Ontell M, Klueber K
Ontogenez. 1983 Jan-Feb;14(1):3-20.
During the past 50 years there have been significant advances in our understanding of striated muscle development, both from tissue culture studies and from observations of myogenesis in the developing foetus. Experiments, using the distinctive nucleolar marker of quail nuclei, have led to reexamination of the source of the body's muscle masses. Advances have been made in our understanding of the events which occur and mechanisms involved in the formation of multinucleated myofibers from mononucleated myoblasts. Recently, the development of entire muscle organs has been studied. The present review attempts to synthesize the results of both in vivo and in vitro studies of myogenesis, comparing both their similarities and their differences. Attention has been focused on recent advances in our understanding of the source of muscles in the intact foetus, the formation of extrafusal and intrafusal fibers, and the development of the afferent and efferent neuromuscular relationships.
在过去的50年里，我们对横纹肌发育的理解取得了重大进展，这既来自组织培养研究，也来自对发育中胎儿肌生成的观察。使用鹌鹑细胞核独特的核仁标记进行的实验，促使人们重新审视身体肌肉团块的来源。我们对从单核成肌细胞形成多核肌纤维所发生的事件及相关机制的理解也取得了进展。最近，对整个肌肉器官的发育进行了研究。本综述试图综合肌生成的体内和体外研究结果，比较它们的异同。重点关注了我们在完整胎儿肌肉来源、梭外肌纤维和梭内肌纤维的形成以及传入和传出神经肌肉关系发育等方面理解的最新进展。
