Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom ; Escola de Ciências da Saúde, Universidade do Minho, Braga, Portugal.
PLoS Biol. 2014 Jan;12(1):e1001756. doi: 10.1371/journal.pbio.1001756. Epub 2014 Jan 7.
There is growing concern that poor experimental design and lack of transparent reporting contribute to the frequent failure of pre-clinical animal studies to translate into treatments for human disease. In 2010, the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were introduced to help improve reporting standards. They were published in PLOS Biology and endorsed by funding agencies and publishers and their journals, including PLOS, Nature research journals, and other top-tier journals. Yet our analysis of papers published in PLOS and Nature journals indicates that there has been very little improvement in reporting standards since then. This suggests that authors, referees, and editors generally are ignoring guidelines, and the editorial endorsement is yet to be effectively implemented.
人们越来越担心，实验设计不佳和缺乏透明报告导致临床前动物研究经常无法转化为人类疾病的治疗方法。2010 年，引入了《动物研究：体内实验报告的规范》（ARRIVE）指南，以帮助提高报告标准。这些指南发表在《公共科学图书馆·生物学》（PLOS Biology）上，并得到了资助机构和出版商及其期刊的认可，包括《公共科学图书馆》（PLOS）、自然研究期刊（Nature research journals）和其他顶级期刊。然而，我们对发表在《公共科学图书馆》和《自然》期刊上的论文的分析表明，自那时以来，报告标准几乎没有任何改善。这表明作者、审稿人和编辑通常都忽略了这些指南，而编辑认可尚未得到有效实施。
