硒代阿昔洛韦和硒代更昔洛韦：抗病毒药物新模板的发现
Selenoacyclovir and Selenoganciclovir: Discovery of a New Template for Antiviral Agents.
作者信息
Sahu Pramod K, Umme Tamima, Yu Jinha, Nayak Akshata, Kim Gyudong, Noh Minsoo, Lee Jae-Young, Kim Dae-Duk, Jeong Lak Shin
机构信息
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University , Seoul 151-742, Korea.
College of Pharmacy, Ewha Womans University , Seoul 120-750, Korea.
出版信息
J Med Chem. 2015 Nov 12;58(21):8734-8. doi: 10.1021/acs.jmedchem.5b00804. Epub 2015 Oct 23.
On the basis of the potent antiviral activity of acyclovir and ganciclovir, selenoacyclovir (2a) and selenoganciclovir (2b) were designed based on bioisoteric rationale and synthesized via the diselenide 7 as the key intermediate. Compound 2a exhibited potent anti-HSV-1 and -2 activities while 2b exerted moderate anti-HCMV activity, indicating that these nucleosides can serve as a novel template for the development of new antiviral agents.
基于阿昔洛韦和更昔洛韦强大的抗病毒活性，基于生物电子等排原理设计了硒代阿昔洛韦（2a）和硒代更昔洛韦（2b），并通过二硒化物7作为关键中间体进行合成。化合物2a表现出强大的抗单纯疱疹病毒1型和2型活性，而2b则具有中等抗人巨细胞病毒活性，这表明这些核苷可作为开发新型抗病毒药物的新模板。
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