Drummond D C, Turkington D, Rahman M Z, Mullin P J, Jackson P
Addiction Research Unit, Institute of Psychiatry, London, U.K.
Drug Alcohol Depend. 1989 Jan;23(1):63-71. doi: 10.1016/0376-8716(89)90035-5.
A double blind trial of chlordiazepoxide vs. methadone in the management of the opiate withdrawal syndrome was conducted in a group of 24 regular heroin takers. Subjective and objective measures including physiological parameters were recorded to compare the severity of opiate withdrawal between the two groups. No significant difference was found in terms of subjective withdrawal distress between the two treatment conditions, although there was a tendency to a return of withdrawal symptoms in the methadone group towards the end of treatment. A nurse rating scale demonstrated a significantly higher level of withdrawal signs in the chlordiazepoxide group on day 3. Physiological measures suggested that neither group experienced a severe withdrawal illness. A similar number in each group (37%) became completely drug free.
对一组24名经常吸食海洛因者进行了一项关于氯氮䓬与美沙酮治疗阿片戒断综合征的双盲试验。记录了包括生理参数在内的主观和客观指标，以比较两组之间阿片戒断的严重程度。尽管美沙酮组在治疗接近尾声时有戒断症状复发的趋势，但两种治疗条件下的主观戒断痛苦并无显著差异。护士评定量表显示，在第3天，氯氮䓬组的戒断体征水平明显更高。生理指标表明，两组均未出现严重的戒断症状。每组中相似比例（37%）的人完全戒毒。
