Psychiatry and Behavioral Sciences Research Center, Department of Psychiatry, Mazandaran, University of Medical Sciences and Health Services, Sari, Iran.
J Addict Dis. 2012;31(2):112-7. doi: 10.1080/10550887.2012.665728.
The aim of this study was to compare the efficacy and safety of tramadol versus methadone for treatment of opiate withdrawal. Seventy patients randomly were assigned in two groups to receive either prescribed methadone (60 mg/day) or tramadol (600 mg/day). The withdrawal syndrome of patients was evaluated before and after rapid opiate detoxification using the Objective Opioid Withdrawal Scale (OOWS). No significant differences existed in overall OOWS scores between two groups (P = 0.11). Dropout rates were similar in both groups. Side effects in the tramadol group were as or less common than in the methadone group, with the exception of perspiration. Tramadol may be as effective as methadone in the control of withdrawal and could be considered as a potential substitute for methadone to manage opioids withdrawal.
本研究旨在比较曲马多与美沙酮治疗阿片类药物戒断的疗效和安全性。70 例患者随机分为两组，分别接受美沙酮（60mg/天）或曲马多（600mg/天）治疗。使用客观阿片类戒断量表（OOWS）在快速阿片类药物解毒前后评估患者的戒断综合征。两组的总体 OOWS 评分无显著差异（P=0.11）。两组的辍学率相似。曲马多组的副作用与美沙酮组一样常见或更少，除了出汗。曲马多在控制戒断方面可能与美沙酮一样有效，可以考虑作为美沙酮的潜在替代品来管理阿片类药物戒断。
