基因组完整性与衰老大脑。
Genomic integrity and the ageing brain.
机构信息
Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.
Institute for Advanced Study, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.
出版信息
Nat Rev Neurosci. 2015 Nov;16(11):672-84. doi: 10.1038/nrn4020. Epub 2015 Oct 14.
DNA damage is correlated with and may drive the ageing process. Neurons in the brain are postmitotic and are excluded from many forms of DNA repair; therefore, neurons are vulnerable to various neurodegenerative diseases. The challenges facing the field are to understand how and when neuronal DNA damage accumulates, how this loss of genomic integrity might serve as a 'time keeper' of nerve cell ageing and why this process manifests itself as different diseases in different individuals.
DNA 损伤与衰老过程相关，并可能推动其发生。大脑中的神经元是后分裂的，被排除在许多形式的 DNA 修复之外；因此，神经元易患各种神经退行性疾病。该领域面临的挑战是要了解神经元 DNA 损伤是如何以及何时积累的，基因组完整性的这种丧失如何作为神经细胞衰老的“计时器”，以及为什么这个过程在不同个体中表现为不同的疾病。
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