在抑制犬尿喹啉酸内源性合成的条件下，由犬尿喹啉酸引起的实验性糖尿病动物胰岛的组织学变化。
Histological Changes in Pancreatic Islets of Animals with Experimental Diabetes Caused by Xanthurenic Acid under Condition of Suppression of Its Endogenous Synthesis.
作者信息
Meyramov G G, Kohnert К-D, Kikimbaeva А А, Аitkulov А М, Кystaubaeva Z T, Тykeshanova G M, Dupont O-N, Laryushina Е М, Меyramova А G, Zhuzbaeva G O, Коvalenko О L, Shaybek A S
机构信息
Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan.
E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan.
出版信息
Bull Exp Biol Med. 2015 Sep;159(5):680-4. doi: 10.1007/s10517-015-3046-y. Epub 2015 Oct 14.
Long-term administration of pyridoxine to rats kept on a diabetogenic diet stimulating endogenous synthesis of xanthurenic acid resulted in minimal glycemia, less pronounced decrease in insulin content in β-cells, and more intensive excretion of xanthurenic acid with urine. Histological changes were observed in 23% pancreatic islets, whereas in rats not treated with pyridoxine, destruction and necrosis of 40-45% β-cells were found in 38% of studied islets.
给食用致糖尿病饮食以刺激内源性黄尿酸合成的大鼠长期施用吡哆醇，可使血糖降至最低水平，β细胞中胰岛素含量的降低不太明显，且黄尿酸随尿液的排泄更为强烈。在23%的胰岛中观察到组织学变化，而在未用吡哆醇治疗的大鼠中，在38%的研究胰岛中发现40 - 45%的β细胞发生破坏和坏死。
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