Rauscher Emily, Conley Dalton, Siegal Mark L
University of Kansas, Department of Sociology, 1415 Jayhawk Blvd. Room 716, Lawrence, KS 66045, United States.
New York University & NBER, Department of Sociology, 6 Washington Square North Room 20, New York, NY 10003, United States.
Soc Sci Res. 2015 Nov;54:209-20. doi: 10.1016/j.ssresearch.2015.08.002. Epub 2015 Aug 18.
While research consistently suggests siblings matter for individual outcomes, it remains unclear why. At the same time, studies of genetic effects on health typically correlate variants of a gene with the average level of behavioral or health measures, ignoring more complicated genetic dynamics. Using National Longitudinal Study of Adolescent Health data, we investigate whether sibling genes moderate individual genetic expression. We compare twin variation in health-related absences and self-rated health by genetic differences at three locations related to dopamine regulation and transport to test sibship-level cross-person gene-gene interactions. Results suggest effects of variation at these genetic locations are moderated by sibling genes. Although the mechanism remains unclear, this evidence is consistent with frequency dependent selection and suggests much genetic research may violate the stable unit treatment value assumption.
虽然研究一直表明兄弟姐妹对个体的结果很重要，但原因尚不清楚。与此同时，对健康的基因效应的研究通常将基因变体与行为或健康指标的平均水平相关联，而忽略了更复杂的基因动态。利用青少年健康全国纵向研究数据，我们调查了兄弟姐妹的基因是否会调节个体的基因表达。我们通过与多巴胺调节和转运相关的三个位点的基因差异，比较了与健康相关的缺勤和自评健康方面的双胞胎差异，以测试同胞水平的跨人基因-基因相互作用。结果表明，这些基因位点的变异效应受到兄弟姐妹基因的调节。尽管机制尚不清楚，但这一证据与频率依赖性选择一致，并表明许多基因研究可能违反了稳定单位治疗值假设。
