Domingue Benjamin W, Rehkopf David H, Conley Dalton, Boardman Jason D
is assistant professor of education at Stanford University.
is assistant professor of medicine at the Stanford University School of Medicine.
RSF. 2018 Apr;4(4):137-149. doi: 10.7758/rsf.2018.4.4.08.
We interrogate state-level clustering of polygenic scores at different points in the life course and variation in the association of mean polygenic scores in a respondent's state of birth with corresponding phenotypes. The polygenic scores for height and smoking show the most state-level clustering (2 to 4 percent) with relatively little clustering observed for the other scores. However, even the small amounts of observed clustering are potentially meaningful. The state-mean polygenic score for educational attainment is strongly associated with an individual's educational attainment net of that person's polygenic score. The ecological clustering of polygenic scores may denote a new environmental factor in gene-environment research. We conclude by discussing possible mechanisms that underlie this association and the implications of our findings for social and genetic research.
我们探究了不同生命阶段多基因分数的州级聚类情况，以及受访者出生州的平均多基因分数与相应表型之间关联的变化。身高和吸烟的多基因分数呈现出最多的州级聚类（2%至4%），而其他分数的聚类则相对较少。然而，即使是观察到的少量聚类也可能具有意义。教育程度的州平均多基因分数与个人的教育程度密切相关，且不受该人多基因分数的影响。多基因分数的生态聚类可能代表了基因-环境研究中的一个新环境因素。我们通过讨论这种关联背后可能的机制以及我们的发现对社会和基因研究的意义来得出结论。
