Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal.
Centre of Physical Activity, Health and Leasure, Faculty of Sport, University of Porto, Rua Plácido Costa 91, 4200-450, Porto, Portugal.
Basic Res Cardiol. 2015 Nov;110(6):57. doi: 10.1007/s00395-015-0514-5. Epub 2015 Oct 13.
Clinical studies suggest that aerobic exercise can exert beneficial effects in pulmonary arterial hypertension (PAH), but the underlying mechanisms are largely unknown. We compared the impact of early or late aerobic exercise training on right ventricular function, remodeling and survival in experimental PAH. Male Wistar rats were submitted to normal cage activity (SED), exercise training in early (EarlyEX) and in late stage (LateEX) of PAH induced by monocrotaline (MCT, 60 mg/kg). Both exercise interventions resulted in improved cardiac function despite persistent right pressure-overload, increased exercise tolerance and survival, with greater benefits in EarlyEX+MCT. This was accompanied by improvements in the markers of cardiac remodeling (SERCA2a), neurohumoral activation (lower endothelin-1, brain natriuretic peptide and preserved vascular endothelial growth factor mRNA), metabolism and mitochondrial oxidative stress in both exercise interventions. EarlyEX+MCT provided additional improvements in fibrosis, tumor necrosis factor-alpha/interleukin-10 and brain natriuretic peptide mRNA, and beta/alpha myosin heavy chain protein expression. The present study demonstrates important cardioprotective effects of aerobic exercise in experimental PAH, with greater benefits obtained when exercise training is initiated at an early stage of the disease.
临床研究表明，有氧运动对肺动脉高压（PAH）有有益的影响，但潜在的机制在很大程度上尚不清楚。我们比较了早期或晚期有氧运动训练对实验性 PAH 右心室功能、重构和生存的影响。雄性 Wistar 大鼠接受正常笼活动（SED）、MCT（60mg/kg）诱导的 PAH 早期（EarlyEX）和晚期（LateEX）有氧运动训练。尽管右心室压力超负荷持续存在，但两种运动干预都改善了心功能，增加了运动耐量和存活率，早期运动组（EarlyEX+MCT）获益更大。这伴随着心脏重构标志物（SERCA2a）、神经激素激活（降低内皮素-1、脑钠肽和保留血管内皮生长因子 mRNA）、代谢和线粒体氧化应激的改善。早期运动组（EarlyEX+MCT）还改善了纤维化、肿瘤坏死因子-α/白细胞介素-10 和脑钠肽 mRNA 以及β/α肌球蛋白重链蛋白的表达。本研究表明，有氧运动对实验性 PAH 具有重要的心脏保护作用，当疾病早期开始运动训练时，益处更大。
